Acne is a skin condition characterized by clogged pores (blackheads and whiteheads), pimples, and even deeper lumps (cysts or nodules) on the face, neck, chest, back, shoulders, and upper arms. Acne affects the majority of teenagers to some degree. Acne, on the other hand, affects people of all ages; it can affect people in their 20s and even their 40s. Acne can be unpleasant and disfiguring, despite the fact that it is not a life-threatening condition. Acne, if left untreated, can leave scarring that is permanent. Scarring can occur in even the mildest of situations. What causes acne to appear?
- The release of inflammatory fatty acids by a specific bacterium known as p.acnes leads the body's defense systems to respond, resulting in an inflamed area.
- However, p.acnes colonization of the hair follicle channel would not be possible without a clog developing.
- An increase in skin cell turnover, increased keratin deposition narrowing the aperture of the hair follicle duct, combined with increased sebum production, causes a blockage and a clog to form.
- If linoleic acid levels in the skin had dropped considerably, the increased sebum, keratin, and cell turnover would not have occurred.
- Linoleic acid levels dropped as a result of increased sensitivity to the hormone DHT.
- Testosterone is used to make DHT. The chemical reaction occurs naturally throughout the body, and the enzyme 5-alpha reductase aids and promotes the conversion of testosterone to DHT. (Enzymes control and accelerate all chemical reactions in the body.)
Possible treatments for acne's underlying causes include:
1) Eliminate hormonal swings. Although some people try using plant hormones, HRT, and royal jelly, this is impossible. But, in general, we should avoid disrupting our normal hormonal balance.
2) Take a course of Roaccutane. This will influence testosterone conversion to DHT, but this will happen all over the body, and DHT is involved in a lot of physiological activities, so inhibiting it can have a number of negative consequences.
3) Reduce DHT levels only in the pilo-sebaceous unit (hair follicle and sebaceous gland area). If it were feasible to prevent testosterone from converting to DHT in the acne area of the skin while leaving this conversion unaffected elsewhere in the body, skin sensitisation and linoleic acid loss may be reduced without harming testosterone to DHT conversion elsewhere in the body. In theory, if one could adjust the environment in the pilosebaceous unit for a lengthy period of time so that DHT levels were lowered locally during times in our lives when normal hormone levels were ‘out of sync,' a topical preparation may reduce the triggering of the acne process. Two harmless products termed tri-ethyl citrate and ethyl linoleate, which release citric acid and linoleic acid, can alter skin conditions, slowing the enzyme 5-alpha reductase and hence testosterone conversion to DHT locally. The conversion of testosterone to DHT will still happen, but it will happen someplace else in the body, thus other physical functions will be unaffected.
4) If linoleic acid levels in the skin could be replenished, oil production, skin cell turnover, and keratin deposition would all slow down, preventing the plug from developing and p.acnes colonization.
5) Linoleic acid supplements and meals high in linoleic acid are available. However, because linoleic acid is needed by many regions of the body, oral supplementation alone would have to be at potentially dangerous amounts to have a meaningful effect on skin levels. It has been noted that the Eskimos (the Inuit) did not suffer from acne until they were introduced to western diets, thus doing so without going overboard is definitely a beneficial thing. However, if a means to boost skin linoleic acid levels with a topical treatment can be found, this could help with the acne process.
6) Getting linoleic acid into the skin is difficult, but sophisticated delivery technologies including specific molecular structures in creams like Oleosomes and approaches with fancy names like Drysyst technology can help. If ethyl linoleate is used, skin bacteria will assist in breaking it down and releasing linoleic acid into the skin (look for products containing ethyl linoleate.)
7) Cell turnover could be normalized to prevent skin thickness and keratin increases in skin cells. This would help prevent the pilo-sebaceous duct from becoming blocked. Creams containing retinol A have been demonstrated to improve skin cell turnover rates. However, greater sensitivity to UV and even an increased risk of skin cancer are potential negative effects of retinol products. As a result, users of retinol-based cosmetics are highly encouraged to apply a high-SPF sunscreen while using them. Triethyl citrate is a compound that normalizes keratin deposition and skin cell turnover rates while preventing photosensitivity (please search for products containing triethyl citrate).
8) Reduce the amount of oil on your skin. This is usually accomplished by employing detergents to reduce the amount of oil on the surface. Doing so on its own simply leads to increased oil production, resulting in a downward cycle with a "negative feedback loop" that leads to increased sebum (oil) production. Oil control, on the other hand, is critical, and using mild detergents can help regulate the acne process. In a clinical research published in the British Journal of Dermatology at the end of 2007, using a combination of triethyl citrate and ethyl linoleate, sebum production rates were lowered by up to 68 percent, with an average of 55 percent.
9) Exfoliants and detergents can assist unclog ducts by dissolving and eliminating blockages, as well as lowering skin thickness and skin debris levels. This is effective and can assist, however exfoliants can make inflamed and painful skin even more sensitive and sore. Chemical exfoliants may be preferable to irritant-inducing physical exfoliants. Better still, employ hydroxy acids like Salicylic acid and Pyruvic acid, which have been demonstrated to influence sebum production rates (also known as fruit acids). These are the only two that have showed a sebo-static effect, which means that oil production is momentarily slowed. Glycolic acid is another typical chemical exfoliator, however it has not been demonstrated to have a sebo-static effect. Salicylic acid has also been demonstrated to loosen skin cells, which aids in skin thickening. (See Salicylic and Pyruvic acid-containing products.)
10) Even products containing fruit acids might irritate some skins, and some acne patients, particularly those with younger skin, can be extremely sensitive and lack considerable skin thickness. One could use a gentle, non-irritating cleansing agent containing silicone and glucose-based cleansers that are very gentle on the skin and also contain triethyl citrate, which will normalize skin thickening by addressing overactive skin cell turnover and thus addressing skin thickening from within the skin.
11) Keep p.acnes levels in check. One method is to keep hair follicle conduits open and oxygenated, but blockages can still occur. So, if you're going to control P.acnes, do so without treating skin staphylococci, as previously indicated, because MRSA growth is a danger. Antibiotics can be used to do this, and they may be indicated in pustular scarring acne, but most of us are aware that p.acnes releases enzymes to break down the clog and release nourishing fatty acids, which can also trigger an inflammatory reaction in the body. If you alter the conditions in the pilosebaceous unit so that these enzymes don't work as well, you can slow down the process, lower the amount of food consumed, and so minimize the growth of p.acnes without harming the healthy bacteria on your skin (staphs) (see an example of how this ca be achieved)
12) Lower your inflammatory levels. Anti-inflammatory medications, as well as bacteria-controlling products, can help to reduce inflammation. Another strategy to manage inflammation is to stop the generation of inflammatory fatty acids, but cleaning up the inflammatory free radicals created is also a viable option. Antioxidants are beneficial in this sense, and the greatest antioxidants are probably skin-soluble versions of vitamin C like ascorbic acid and others like Ascorbyl Palmitate and notably Ascorbyl tetra-isopalmitate (see an example of a product containing these).
In conclusion
If you have a product line that includes mild sebostatic chemical exfoliants, silicone and glucose-based cleansers, and changes conditions to slow DHT production locally, increase linoleic acid levels in the skin, normalize skin cell turnover, keratin deposits, and sebum production while also having mild sebostatic chemical exfoliants. If this product also included staph-friendly antibacterials to control p.acnes, feeding, and development, as well as antioxidants to help control the inflammatory process, you'd have a highly effective product range that could be obtained with or without a prescription and is backed by eminent dermatologists all over the world, including the UK's top acne dermatologist, who has had hiv-positive patients. You'd assume that if this medicine was really inexpensive, it would dominate the acne treatment market.
0 comments:
Post a Comment